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KMID : 0882420090760020220
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Korean Journal of Medicine
2009 Volume.76 No. 2 p.220 ~ p.224
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Allopurinol hypersensitivity syndrome and pure red cell aplasia associated with allopurinol treatment
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Lee Jin-Ho
Heo Jong-Hoon
Kwon Kyung-A
Han Dae-Hui
Hwang Jong-Woon
Cho Seung
Kim Sung-Rok
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Abstract
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Allopurinol is widely used to reduce serum uric acid levels and, generally, has mild side effects. Rarely, allopurinol hypersensitivity syndrome occurs and this consists of severe systemic skin lesions, fever, reduced kidney and liver function, and leukocytosis with eosinophilia. Extremely rarely, allopurinol-induced pure red cell aplasia is reported. We report a case of allopurinol hypersensitivity syndrome and pure red cell aplasia following allopurinol therapy for eight weeks and the disease response to steroid therapy in a patient with chronic renal insufficiency. (Korean J Med 76:220-224, 2009)
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KEYWORD
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Allopurinol, Pure red-cell aplasia
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